Urea → HCID 178462969, compound

HRID 1680957Notes

Reaction equation

HRID 1680957 reaction equation
[NH2:1][C:2]1[C:3]([NH:12][CH2:13][CH3:14])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.N[C:16](N)=[O:17]>O>[CH2:13]([N:12]1[C:3]2[CH:4]=[CH:5][C:6]3[CH:7]=[CH:8][CH:9]=[N:10][C:11]=3[C:2]=2[N:1]=[C:16]1[OH:17])[CH3:14]

Participants

4

Reactant 2

HCID 1176UreaHCID 15023104HCID 15023104, compound

Product 1

HCID 178462969HCID 178462969, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
140 °C

Procedure

22.4 g (0.12 mol) of 8-amino-7-ethylaminoquinoline and 9 g (0.15 mol) of urea are heated at 160° C. for 2 h, stirring vigorously. The mixture is allowed to cool to 140° C., and 50 ml of water are slowly added dropwise. After further cooling to 100° C., another 100 ml of water are added. The precipitate is filtered off with suction, washed again with hot water and dried under reduced pressure.

Workup

  1. temperatureAfter further cooling to 100° C.
  2. filtrationThe precipitate is filtered off with suction
  3. washwashed again with hot water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-214ebce0711442b9802d432037f5ea1b
Source dataset
uspto-grants-1992_12
Patent number
US05167695

Reaction notes

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