HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3,4-Difluorobenzene-1-carboximidamide--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3,4-Difluorobenzonitrile | HCID 587203 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,4-Difluorobenzene-1-carboximidamide--hydrogen chloride (1/1) | HCID 19807851 | — |
Reaction Steps
3,4-difluorobenzonitrile (4) is reacted with dried HCl gas in anhydrous methanol, followed by reacting the resulting crystals with dried ammonia gas in anhydrous ethanol to obtain 3,4-difluorobenzamidine hydrochloride (5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05167858 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-4d88536cab404acf9521d1b58e31f1b6 |
| Source note | uspto-grants-1992_12 |