Ammonia → 3,4-Difluorobenzene-1-carboximidamide--hydrogen chloride (1/1)

HRID 1680974Notes

Reaction equation

HRID 1680974 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[C:5]#[N:6].[ClH:11].[NH3:12]>CO.C(O)C>[ClH:11].[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[C:5]([NH2:12])=[NH:6]

Participants

6

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 5872033,4-Difluorobenzonitrile

Product 1

HCID 198078513,4-Difluorobenzene-1-carboximidamide--hydrogen chloride (1/1)

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

3,4-difluorobenzonitrile (4) is reacted with dried HCl gas in anhydrous methanol, followed by reacting the resulting crystals with dried ammonia gas in anhydrous ethanol to obtain 3,4-difluorobenzamidine hydrochloride (5).

Sources & evidence

ORD record
ord-4d88536cab404acf9521d1b58e31f1b6
Source dataset
uspto-grants-1992_12
Patent number
US05167858

Reaction notes

Loading…