Acetic Acid → 2-(4-hydroxyphenyl)benzoic Acid

HRID 1680996Notes

Reaction equation

HRID 1680996 reaction equation
C[O:2][C:3]1(C(O)=O)[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][CH2:4]1.[C:18]([OH:21])(=[O:20])C.Br(O)(=O)=O>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:10]([C:18]([OH:21])=[O:20])=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24445Bromic acidHCID 68967877HCID 68967877, compound

Product 1

HCID 27593032-(4-hydroxyphenyl)benzoic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 25 g of 4-methoxybiphenyl-4-carboxylic acid, 1 1 of acetic acid and 200 ml of 48% bromic acid was refluxed for 12-14 hours and then thrown into 2.5 l of water. After cooling, the resultant crystal was collected to obtain 4'-hydroxybiphenylcarboxylic acid.

Workup

  1. temperaturewas refluxed for 12-14 hours
  2. temperatureAfter cooling
  3. customthe resultant crystal was collected

Sources & evidence

ORD record
ord-2080b711621249c8bd03adae57f46184
Source dataset
uspto-grants-1992_12
Patent number
US05167857

Reaction notes

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