Oxalyl chloride → HCID 57059107, compound

HRID 1680999Notes

Reaction equation

HRID 1680999 reaction equation
[CH2:1]([O:5][C@@H:6]([CH3:12])[C@@H:7]([CH3:11])[C:8](O)=[O:9])[CH2:2][CH2:3][CH3:4].C(Cl)(=O)C([Cl:16])=O>>[CH2:1]([O:5][C@@H:6]([CH3:12])[C@@H:7]([CH3:11])[C:8]([Cl:16])=[O:9])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 57155902HCID 57155902, compound

Product 1

HCID 57059107HCID 57059107, compound

Procedure

To 1.1 g of the (2R,3S)-3-butoxy-2-methylbutyric acid produced in the above i) was added in small portions 5 ml of oxalyl chloride at room temperature. The mixture was stirred for 2 hours at room temperature and then for 30 minutes at 50° C. Excess oxalyl chloride was removed by distillation under reduced pressure. The residue was subjected to Kugel-rohr distillation under reduced pressure to obtain 0.88 g of (2R,3S)-3-butoxy-2-methylbutyric acid chloride.

Workup

  1. waitfor 30 minutes at 50° C
  2. customExcess oxalyl chloride was removed by distillation under reduced pressure
  3. distillationThe residue was subjected to Kugel-rohr distillation under reduced pressure

Sources & evidence

ORD record
ord-ecadfdfb909b47f1bc8d33409f37c42a
Source dataset
uspto-grants-1992_12
Patent number
US05167863

Reaction notes

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