Acetic Acid → Lcb-2183

HRID 1681010Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1681010
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][CH2:14][CH3:15])[N:3]=1.C(O)(=[O:18])C>[OH-].[Na+]>[CH2:14]([O:13][CH2:12][C:4]1[NH:3][C:2](=[O:18])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1)[CH3:15]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 107982772-(Ethoxymethyl)pteridin-4-amine

Produkt 1

HCID 135418284Lcb-2183

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of 30.0 g (0.146 mole) of 4-amino-2-(ethoxymethyl)pteridine in 800 ml of 5% aqueous sodium hydroxide is brought slowly to 75° C. and maintained at this temperature for 2 hours. After cooling, the solution obtained is acidified with acetic acid to pH 6 and is then extracted with chloroform. The organic extracts are dried over sodium sulphate and concentrated to dryness under reduced pressure. The solid residue is recrystallized from ethanol in the presence of Norit. Yld: 19.5 g (65%), m.p.=168°-169° C. The product is identical to that obtained in Example 1.

Aufarbeitung

  1. customis brought slowly to 75° C.
  2. temperaturemaintained at this temperature for 2 hours
  3. temperatureAfter cooling
  4. customthe solution obtained
  5. extractionis then extracted with chloroform
  6. dry with materialThe organic extracts are dried over sodium sulphate
  7. concentrationconcentrated to dryness under reduced pressure
  8. customThe solid residue is recrystallized from ethanol in the presence of Norit
  9. customthat obtained in Example 1

Quellen und Nachweise

ORD-Eintrag
ord-fae656b4c2a740e9bfcd541d2a727474
Quelldatensatz
uspto-grants-1992_12
Patentnummer
US05167949

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