HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Phenoxymethyl-4(3H)-pteridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Amino-2-(phenoxymethyl)pteridine | HCID 10634626 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Phenoxymethyl-4(3H)-pteridinone | HCID 135463628 | — |
Reaction Steps
A mixture of 4.0 g (0.016 mole) of 4-amino-2-(phenoxymethyl)pteridine and 400 ml of 5% aqueous sodium hydroxide is brought slowly to 95° C. and maintained at this temperature for 2 hours. After cooling, the solution obtained is acidified with acetic acid to pH 5.5. The precipitate formed is isolated by filtration. It is purified by recrystallization from ethanol. Yld: 2.8 g (70%), m.p. 220°-221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05167949 |
| Source dataset | uspto-grants-1992_12 |
| ORD ID | ord-b881cdfa923545008924e96f765404c1 |
| Source note | uspto-grants-1992_12 |