HCID 10543796, compound → HCID 135493470, compound

HRID 1681038Notes

Reaction equation

HRID 1681038 reaction equation
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[N:3]=1.C([OH:24])C.CN(C)C=O>[OH-].[Na+]>[Cl:21][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[Cl:20])[O:13][CH2:12][C:4]1[NH:3][C:2](=[O:24])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 10543796HCID 10543796, compoundHCID 19794673N,N-dimethylformamide ethanol

Product 1

HCID 135493470HCID 135493470, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Obtained using the procedure described in section b of Example 9, starting with 15.0 g (0.0466 mole) of 4-amino-2-[(3,4-dichlorophenoxy)methyl]pteridine in 1500 ml of 5% aqueous sodium hydroxide. Heating time: 6 hours under reflux. Yld: 10.0 g (66%), m.p. 285°-287° C. (ethanol/N,N-dimethylformamide).

Workup

  1. customObtained
  2. temperatureHeating time
  3. temperature6 hours under reflux

Sources & evidence

ORD record
ord-500baee714bb4d25836e300da45b6fcf
Source dataset
uspto-grants-1992_12
Patent number
US05167949

Reaction notes

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