Hydrochloric Acid → HCID 14721525, compound

Participants

Reaction Steps

573 g(2.65 mol) of methyl 1-methyl-2-chloro-2,3,3-trifluor-cyclobutane-1-carboxylate, 233 g (5.8 mol) of sodium hydroxide and 1000 ml of water are stirred at 80° C.for three hours. The mixture is acidifed with concentrated hydrochloric acid and extracted with dichloromethane, and the organic phases are dried and distilled. 472 g (88% of theory) of 1-methyl-2-chloro2,3,3-trifluoro-cyclobutane-1-carboxylic acid are obtained, boiling point: 112°-116° C./21.4 mbar (60% transisomer, 40% cis-isomer).

Provenance & Evidence