Hydrochloric Acid → HCID 14721525, compound

HRID 1681089Notes

Reaction equation

HRID 1681089 reaction equation
[CH3:1][C:2]1([C:10]([O:12]C)=[O:11])[CH2:5][C:4]([F:7])([F:6])[C:3]1([Cl:9])[F:8].[OH-].[Na+].Cl>O>[CH3:1][C:2]1([C:10]([OH:12])=[O:11])[CH2:5][C:4]([F:7])([F:6])[C:3]1([Cl:9])[F:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14721524HCID 14721524, compound

Product 1

HCID 14721525HCID 14721525, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

573 g(2.65 mol) of methyl 1-methyl-2-chloro-2,3,3-trifluor-cyclobutane-1-carboxylate, 233 g (5.8 mol) of sodium hydroxide and 1000 ml of water are stirred at 80° C.for three hours. The mixture is acidifed with concentrated hydrochloric acid and extracted with dichloromethane, and the organic phases are dried and distilled. 472 g (88% of theory) of 1-methyl-2-chloro2,3,3-trifluoro-cyclobutane-1-carboxylic acid are obtained, boiling point: 112°-116° C./21.4 mbar (60% transisomer, 40% cis-isomer).

Workup

  1. extractionextracted with dichloromethane
  2. customthe organic phases are dried
  3. distillationdistilled

Sources & evidence

ORD record
ord-8b1d4cfe702c408f8c5cf68416b9e894
Source dataset
uspto-grants-1992_12
Patent number
US05169427

Reaction notes

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