3,4,5,6-Tetrahydrophthalic anhydride → N-(4-chloro-5-hydroxymethylphenyl)-3,4,5,6-tetrahydrophthalimide

참여 물질

반응 단계

To 50 ml of acetic acid, 2.47 g of 3,4,5,6-tetrahydrophthalic anhydride and2.56 g of 4-chloro-5-hydroxymethyl aniline were added and the mixture was heated to reflux under stirring for 16 hours. After cooling, the solvent was evaporated under reduced pressure and the residue was purified by column chromatography (silica gel, benzene/ethyl acetate=10/1 (v/v)) to obtain 1.82 g of the desired product.

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