反应详情

To 50 ml of acetic acid, 2.47 g of 3,4,5,6-tetrahydrophthalic anhydride and2.56 g of 4-chloro-5-hydroxymethyl aniline were added and the mixture was heated to reflux under stirring for 16 hours. After cooling, the solvent was evaporated under reduced pressure and the residue was purified by column chromatography (silica gel, benzene/ethyl acetate=10/1 (v/v)) to obtain 1.82 g of the desired product.

1. temperaturethe mixture was heated
2. temperatureto reflux
3. temperatureAfter cooling
4. customthe solvent was evaporated under reduced pressure
5. customthe residue was purified by column chromatography (silica gel, benzene/ethyl acetate=10/1 (v/v))