Hydrochloric Acid → HCID 15171715, compound

HRID 1681123Notes

Reaction equation

HRID 1681123 reaction equation
C[O-:2].[Na+].C([C:7]1[CH:19]=[CH:18][C:10]2[C:11](=[O:17])[C:12]([Br:16])=[C:13]([CH3:15])[O:14][C:9]=2[CH:8]=1)(=O)C.Cl>CO>[Br:16][C:12]1[C:11](=[O:17])[C:10]2[CH:18]=[CH:19][C:7]([OH:2])=[CH:8][C:9]=2[O:14][C:13]=1[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 15171714HCID 15171714, compound

Product 1

HCID 15171715HCID 15171715, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.2 ml of sodium methylate (8% of Na (w/v) in methanol) are added under an inert atmosphere to a suspension of 2.3 g (7.7.10-3 mol) of 7-acetyl-3-bromo-2-methyl-4H-1-benzopyran-4-one in 40 ml of methanol. After 30 minutes, the reaction mixture is hydrolyzed with an iced solution of hydrochloric acid. The precipitate formed is filtered off and then washed until the pH of the washings is neutral. 1.9 g (yield: 96%) of the expected product are thus obtained.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed until the pH of the washings

Sources & evidence

ORD record
ord-3b36df8fd70442faa974c9ff5b4243e3
Source dataset
uspto-grants-1992_12
Patent number
US05169838

Reaction notes

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