4-Fluorobenzyl bromide → 1-Benzyl-3-(4'-fluorobenzyloxymethyl) piperidine

HRID 1681180Notes

Reaction equation

HRID 1681180 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH2:10]([N:17]1[CH2:22][CH2:21][CH2:20][CH:19]([CH2:23][OH:24])[CH2:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([N:17]1[CH2:22][CH2:21][CH2:20][CH:19]([CH2:23][O:24][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=2)[CH2:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 10398044(1-Benzylpiperidin-3-yl)methanol

Product 1

HCID 542627331-Benzyl-3-(4'-fluorobenzyloxymethyl) piperidine

Procedure

Following the procedure for Example 139, 4-fluorobenzylbromide and 1-benzyl-3-(hydroxy-methyl)piperidine were reacted to give 1-benzyl-3-(4'-fluorobenzyloxymethyl) piperidine.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-26edd8d4c30f4c9b8c061bc97d87c5f2
Source dataset
uspto-grants-1992_12
Patent number
US05169855

Reaction notes

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