反应详情

0.9 ml of piperidine is added to 24.8 g (0.2 mol) of 4-fluorobenzaldehyde and 32.4 g (0.2 mol) of benzyl isopropyl ketone in 150 ml of toluene and the mixture is heated to reflux overnight. After cooling to room temperature, the mixture is extracted several times using water and the organic phase is dried over magnesium sulphate and concentrated in vacuo. The residue is subjected to incipient distillation up to a bath temperature of 150° C. at 0.1 mbar in a high vacuum and 43.8 g of crude product are obtained in the distillation residue.

1. temperaturethe mixture is heated
2. temperatureto reflux overnight
3. extractionthe mixture is extracted several times
4. dry with materialthe organic phase is dried over magnesium sulphate
5. concentrationconcentrated in vacuo
6. distillationdistillation up to a bath temperature of 150° C. at 0.1 mbar in a high vacuum and 43.8 g of crude product
7. customare obtained in the distillation residue