Glyceryl Monooleate → Monoolein Taurocholic acid
Reaction equation
[CH3:1][C@@H:2]([C@@H:14]1[C@@:18]2([CH3:35])[C@@H:19]([OH:34])[CH2:20][C@@H:21]3[C@@:26]4([CH3:32])[CH2:27][CH2:28][C@@H:29]([OH:31])[CH2:30][C@H:25]4[CH2:24][C@@H:23]([OH:33])[C@H:22]3[C@@H:17]2[CH2:16][CH2:15]1)[CH2:3][CH2:4][C:5]([NH:7][CH2:8][CH2:9][S:10]([O-:13])(=[O:12])=[O:11])=[O:6].[Na+:36].[CH3:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]/[CH:45]=[CH:46]\[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][C:54]([O:56][CH2:57][CH:58]([OH:61])[CH2:59][OH:60])=[O:55]>O>[CH3:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]/[CH:45]=[CH:46]\[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][C:54]([O:56][CH2:57][CH:58]([OH:61])[CH2:59][OH:60])=[O:55].[CH3:1][C@@H:2]([C@@H:14]1[C@@:18]2([CH3:35])[C@@H:19]([OH:34])[CH2:20][C@@H:21]3[C@@:26]4([CH3:32])[CH2:27][CH2:28][C@@H:29]([OH:31])[CH2:30][C@H:25]4[CH2:24][C@@H:23]([OH:33])[C@H:22]3[C@@H:17]2[CH2:16][CH2:15]1)[CH2:3][CH2:4][C:5]([NH:7][CH2:8][CH2:9][S:10]([O-:13])(=[O:11])=[O:12])=[O:6].[Na+:36]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.35 g of taurocholic acid was dissolved in 15 ml of de-ionized water and the volume of the solution was increased to 60 ml by adding more deionized water. Then, 0.89 mg of monoolein was slowly added to the solution over 20 mins. using an ice bath on a sonic mixer. The final monoolein and taurocholic acid concentration was 20 mM (the molecular weight of taurocholic acid is 537.7 g and that of monoolein is 356.5 g). The mixture was stored at 10° C.
Workup
- temperaturethe volume of the solution was increased to 60 ml
- customwas stored at 10° C.
Sources & evidence
- ORD record
- ord-09ed34953e8b46caa1e039bb8206abbd
- Source dataset
- uspto-grants-1992_12
- Patent number
- US05169944
Reaction notes
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