Liothyronine → N-Bromoacetyl-3,3',5-triiodothyronine

Participants

Reaction Steps

According to the present invention a solution of 3,3',5-triiodo-L-thyronine and bromoacetyl bromide in ethyl acetate is refluxed for a period of time to produce the bromoacetylated hormone which is then fractionated by high speed countercurrent chromatography to yield highly pure N-bromoacetyl-3,3',5-triiodo-L-thyronine.

Provenance & Evidence