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HRID1681295

反应详情

EQUATION

反应方程式

HRID 1681295 的结构方程式

REACTANTS

反应物

2
结构：N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O
HCID5920

3,5,3'-Triiodothyronine

C15H12I3NO4

结构：O=C(Br)CBr
HCID61147

Acetyl bromide, 2-bromo-

C2H2Br2O

PRODUCTS

生成物

1
结构：O=C(CBr)N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O
HCID122086

N-(2-Bromo-1-hydroxyethylidene)-O-(4-hydroxy-3-iodophenyl)-3,5-diiodotyrosine

C17H13BrI3NO5

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

According to the present invention a solution of 3,3',5-triiodo-L-thyronine and bromoacetyl bromide in ethyl acetate is refluxed for a period of time to produce the bromoacetylated hormone which is then fractionated by high speed countercurrent chromatography to yield highly pure N-bromoacetyl-3,3',5-triiodo-L-thyronine.

WORKUP

后处理

  1. temperatureis refluxed for a period of time
  2. customto produce the bromoacetylated hormone which