Sodium Methoxide → HCID 15067718, compound

HRID 1681310Notes

Reaction equation

HRID 1681310 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:21])[C:7]([NH:11][S:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:14])=[O:13])=[N:8]2)=[C:4](Cl)[N:3]=1.[CH3:23][O-:24].[Na+]>CO>[ClH:1].[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:21])[C:7]([NH:11][S:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:14])=[O:13])=[N:8]2)=[C:4]([O:24][CH3:23])[N:3]=1

Participants

5

Reactant 2

HCID 10942334Sodium MethoxideHCID 15067717HCID 15067717, compound

Product 2

HCID 313Hydrochloric AcidHCID 15067718HCID 15067718, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.00 g (8.00 mmol) of the sulfonamide prepared in Example 1 and 2.90 g (16.0 mmol) of 30% strength sodium methylate solution were stirred in 50 ml of methanol for 12 hours at room temperature, and then evaporated down in a rotary evaporator. Stirring the residue in H2O and acidifying with dilute HCl gave 2.30 g (81%) of the desired product in the form of colorless crystals (active ingredient 1.002).

Workup

  1. customevaporated down in a rotary evaporator

Sources & evidence

ORD record
ord-a31de7b054ee4b0d83199f5bee1a1502
Source dataset
uspto-grants-1992_12
Patent number
US05171353

Reaction notes

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