反应详情

Bis(4-fluorophenyl)methanol was refluxed in toluene with an equimolar amount of bromoethanol in presence of a catalytic amount of p-toluenesulphonic acid. The mixture was refluxed for 12 hrs. in a Dean-Stark apparatus. The solvent was evaporated and the residue was dissolved in ether, washed with water (three times) and brine (three times). The organic layer was dried with sodium sulfate, filtered, concentrated and the residue was purified by distillation to obtain in 80% yield 1-bromo-2-[bis(4-fluorophenyl)methoxy]ethane, b.p. 170° C. at 0.1 mm Hg.

1. temperatureThe mixture was refluxed for 12 hrs
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in ether
4. washwashed with water (three times) and brine (three times)
5. dry with materialThe organic layer was dried with sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. distillationthe residue was purified by distillation