Toluene → 5-Chloro-2-nitrobenzaldehyde diethyacetal

Participants

Reaction Steps

A mixture of 5-chloro-2-nitrobenzaldehyde (5.0 g), toluene (50 ml), p-toluenesulfonic acid monohydrate (25 mg) was heated under stirring for 2 hours by dehydrating water which was formed in the course of reaction. The solvent was distilled under reduced pressure and the residue was column chromatographed (hexane/ethyl acetate: 8/1) to give 6.5 g of the pure title compound (93%).

Provenance & Evidence