HCID 14450253, compound → HCID 14450266, compound

HRID 1681388Notes

Reaction equation

HRID 1681388 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:7]2[CH:8]=[CH:9][C:10]([N+:14]([O-])=O)=[C:11]([CH3:13])[CH:12]=2)[CH:6]=1.[H][H]>[Pd].CO>[NH2:14][C:10]1[CH:9]=[CH:8][C:7]([N:5]2[CH:6]=[C:2]([CH3:1])[N:3]=[CH:4]2)=[CH:12][C:11]=1[CH3:13]

Participants

5

Reactant 2

HCID 14450253HCID 14450253, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14450266HCID 14450266, compoundYield 87.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5-(4-methylimidazol-1-yl)-2-nitrotoluene (198 mg), 10% Pd/C (58 mg) and methanol (3.0 ml) was hydrogenated with hydrogen of 1 atmosphere. The mixture was stirred at room temperature for 2 hours and filtered. The filtrate was distilled under reduce pressure to give 149 mg (87.6%) of the title compound.

Workup

  1. filtrationfiltered
  2. distillationThe filtrate was distilled

Sources & evidence

ORD record
ord-8250fed234b04db287ab4bd857b24f78
Source dataset
uspto-grants-1992_12
Patent number
US05171851

Reaction notes

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