Methanol → HCID 67918065, compound

HRID 1681392Notes

Reaction equation

HRID 1681392 reaction equation
[NH2:1][C:2]1[C:9](C)=[CH:8][C:7]([N:11]2[CH:15]=[C:14]([CH3:16])[N:13]=[CH:12]2)=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+].[CH3:19]O>>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([N:11]2[CH:15]=[C:14]([CH3:16])[N:13]=[CH:12]2)=[CH:6][C:3]=1[CH:4]([OH:5])[CH3:19]

Participants

4

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 19806567HCID 19806567, compound

Product 1

HCID 67918065HCID 67918065, compoundYield 59%

Procedure

2-amino-3-methyl-5-(4-methylimidazol-1-yl)benzaldehyde (57 mg) was dissolved in methanol (1 ml) and sodiumborohydride (40 mg) was added thereto at 0° C. The mixture was stirred at room temperature for 6 hours and was distilled under reduced pressure to remove solvent. To the residue was added water. The mixture was extracted with chloroform. The extract was dried with Na2SO4 and distilled to give 34 mg (59%) of the title compound.

Workup

  1. customat 0° C
  2. distillationwas distilled under reduced pressure
  3. customto remove solvent
  4. additionTo the residue was added water
  5. extractionThe mixture was extracted with chloroform
  6. dry with materialThe extract was dried with Na2SO4
  7. distillationdistilled

Sources & evidence

ORD record
ord-b28bcdf093514a6899f99668d84199ae
Source dataset
uspto-grants-1992_12
Patent number
US05171851

Reaction notes

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