2-Methylimidazole → HCID 13764020, compound

HRID 1681401Notes

Reaction equation

HRID 1681401 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10](F)=[CH:9][CH:8]=1)=O.[CH3:14][C:15]1[NH:16][CH:17]=[CH:18][N:19]=1>>[CH3:14][C:15]1[N:19]2[CH2:2][CH2:3][CH:4]=[C:5]([C:7]3[CH:12]=[CH:11][C:10]([N:16]4[CH:17]=[CH:18][N:19]=[C:15]4[CH3:14])=[CH:9][CH:8]=3)[C:18]2=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 197503-(4-Fluorobenzoyl)propyl chloride

Product 1

HCID 13764020HCID 13764020, compound

Conditions

Temperature
200 °C

Procedure

50 g (0.25 mol) of 4-chloro-4'-fluorobutyrophenone are combined with 130 g (1.58 mol) of 2-methylimidazole and heated to 200° C. under nitrogen for 18 hr. Crystallization from ethyl acetate provides the title compound.

Workup

  1. customCrystallization from ethyl acetate

Sources & evidence

ORD record
ord-eb1a3f8505674f118da69911212c6b5f
Source dataset
uspto-grants-1992_12
Patent number
US05171858

Reaction notes

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