2-Methylimidazole → HCID 13764013, compound

HRID 1681415Notes

Reaction equation

HRID 1681415 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=O.[CH3:13][C:14]1[NH:15][CH:16]=[CH:17][N:18]=1>>[CH3:13][C:14]1[N:18]2[CH2:2][CH2:3][CH:4]=[C:5]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:17]2=[CH:16][N:15]=1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 2535334-Chlorobutyrophenone

Product 1

HCID 13764013HCID 13764013, compound

Procedure

Combine 270 g (1.48 mol) of 4-chlorobutyrophenone with 600 g (7.3 mol) of 2-methylimidazole and heat to 175° C. for 24 hr. Crystallization from ether provides the title compound.

Workup

  1. customCrystallization from ether

Sources & evidence

ORD record
ord-00e44750469b430c94d5050e11e7fb4c
Source dataset
uspto-grants-1992_12
Patent number
US05171858

Reaction notes

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