Potassium Carbonate → HCID 13810565, compound

HRID 1681430Notes

Reaction equation

HRID 1681430 reaction equation
COC([C:5]1[NH:6][C:7](=[O:21])[N:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)[C:9]=12)=O.I[Si](C)(C)C.C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl>[CH3:20][C:17]1[CH:18]=[CH:19][C:14]([C:10]2[C:9]3[N:8]([C:7](=[O:21])[NH:6][CH:5]=3)[CH:13]=[CH:12][CH:11]=2)=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 85247Trimethylsilyl iodideHCID 13810564HCID 13810564, compound

Product 1

HCID 13810565HCID 13810565, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Combine 18 g (64 mmol) of the product of Example X with 19 ml (0.13 mol) of iodotrimethylsilane in 500 ml of methylene chloride and heat to reflux for 24 hr. Cool to room temperature and pour the reaction into 1 liter of 10% potassium carbonate. Dry the methylene chloride portion over magnesium sulfate, treat with charcoal, and remove the solvent in vacuo. Crystallize from ether to provide the title compound.

Workup

  1. temperatureto reflux for 24 hr
  2. additionpour
  3. dry with materialDry the methylene chloride portion over magnesium sulfate
  4. additiontreat with charcoal
  5. customremove the solvent in vacuo
  6. customCrystallize from ether

Sources & evidence

ORD record
ord-f231f089fdc2492aa32254b9769e04fb
Source dataset
uspto-grants-1992_12
Patent number
US05171859

Reaction notes

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