1-Phenethylamine, (+)- → HCID 15671289, compound

HRID 1681435Notes

Reaction equation

HRID 1681435 reaction equation
C[O-].[Na+].[F:4][C:5]1[CH:6]=[CH:7][C:8]2[O:13][C:12]([C:14]([O:16]C)=O)=[CH:11][C:10](=[O:18])[C:9]=2[CH:19]=1.[CH3:20][C@@H:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C1C=CC=CC=1>[CH3:20][C@@H:21]([NH:28][C:14]([C:12]1[O:13][C:8]2[CH:7]=[CH:6][C:5]([F:4])=[CH:19][C:9]=2[C:10](=[O:18])[CH:11]=1)=[O:16])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 6431891-Phenethylamine, (+)-HCID 10942334Sodium MethoxideHCID 14089205Methyl 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylate

Product 1

HCID 15671289HCID 15671289, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Sodium methoxide (540 mg, 10.0 mmol) was added to a solution of methyl 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylate (2.22 g, 10.0 mmol, obtained in Example 3 or 4) and (R)-α-methylbenzylamine (1.21 g, 10.0 mmol) in dry benzene (20 ml) and the mixture was refluxed for 2 hours.

Workup

  1. temperaturethe mixture was refluxed for 2 hours

Sources & evidence

ORD record
ord-db76c8ce8a704c1e837b9e091bf86f90
Source dataset
uspto-grants-1992_12
Patent number
US05171865

Reaction notes

Loading…