5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 19806671, compound

HRID 1681478Notes

Reaction equation

HRID 1681478 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH2:14])=[CH:7][CH:6]=1)[CH3:3].C(O[C:18]1[C:22]([NH2:23])=[C:21]([S:24]([CH3:27])(=[O:26])=[O:25])[S:20](=[O:28])[N:19]=1)C>C(#N)C>[CH3:3][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:18]2[C:22]([NH2:23])=[C:21]([S:24]([CH3:27])(=[O:26])=[O:25])[S:20](=[O:28])[N:19]=2)=[CH:7][CH:6]=1)[CH3:1]

Participants

4

Reactant 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 19806762HCID 19806762, compound

Product 1

HCID 19806671HCID 19806671, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 2-[(5-dimethylaminomethyl-2furanyl)methylthio]ethylamine (440 mg, 2 mmol) in acetonitrile (6 ml) there was added 3-ethoxy-4-amino-5-methylsulfonylisothiazole-1-oxide (480 mg, 2 mmol). This mixture was stirred under a nitrogen atmosphere for 15 hours as product slowly crystallized out. Precipitate was collected by filtration, washed with acetonitrile, diethyl ether and air dried to give 650 mg, of title compound, mp 134°-137°.

Workup

  1. customslowly crystallized out
  2. filtrationPrecipitate was collected by filtration
  3. washwashed with acetonitrile, diethyl ether and air
  4. customdried
  5. customto give 650 mg

Sources & evidence

ORD record
ord-a7f4011d1bb441968a9018d9d4ceb40d
Source dataset
uspto-grants-1992_12
Patent number
US05171860

Reaction notes

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