Piperazine → 1-(Methylsulfonyl)piperazine

HRID 1681519Notes

Reaction equation

HRID 1681519 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[OH-].[Na+]>ClCCl>[CH3:1][S:2]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 4837PiperazineHCID 14798Sodium HydroxideHCID 31297Methanesulfonyl chloride

Product 1

HCID 7091611-(Methylsulfonyl)piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of methanesulfonyl chloride (1.85 ml, 24 mmol) and piperazine (2.06 g, 24 mmol) in dichloromethane (60 ml) was stirred at room temperature for 14 hours. The mixture was basified with aqueous sodium hydroxide and filtered. The filtrate was washed with water, dried (magnesium sulfate) and evaporated down to give the title sulfonamide.

Workup

  1. filtrationfiltered
  2. washThe filtrate was washed with water
  3. dry with materialdried (magnesium sulfate)
  4. customevaporated down

Sources & evidence

ORD record
ord-ccf1efadf210489f86e4b1d609a7511b
Source dataset
uspto-grants-1992_12
Patent number
US05171863

Reaction notes

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