反应详情

Dodecylmagnesium bromide (a 1.0M solution in tetrahydrofuran; 14.3 ml; 14.3 mmol) was added to a solution 2-trimethylsilyl-3-furaldehyde (1.20 g, 7.1 mmol) in tetrahydrofuran (20 ml). When all the aldehyde was consumed, as monitored by tlc, acetic anhydride (2.02 ml, 21.4 mmol) was added Stirring was continued at room temperature for 14 hours. The mixture was quenched with water and was extracted with ethyl ether. Evaporation of the dried (magnesium sulfate) extracts gave an oil, which was purified by a silica column using 2% ethyl ether/hexane to give the titled furan.

1. customWhen all the aldehyde was consumed
2. additionwas added
3. customThe mixture was quenched with water
4. extractionwas extracted with ethyl ether
5. customEvaporation of the
6. dry with materialdried (magnesium sulfate)
7. customextracts gave an oil, which
8. customwas purified by a silica column