反应详情

温度

180 °C

A mixture of 41.5 g of 5-[3-(ethoxycarbonyl)benzoyl]-2-methoxybenzenepropanoic acid, ethyl ester and 410 g of pyridine hydrochloride were heated at 180° C. for 4 hours. After cooling, water was added to the mixture while hot. As the mixture cooled, the title product precipitated from solution. Filtration of the solids and crystallization from ethanol/water provided 31.1 g of the title product, m.p. 197°-200° C.

1. temperatureAfter cooling
2. temperatureAs the mixture cooled
3. customthe title product precipitated from solution
4. filtrationFiltration of the solids and crystallization from ethanol/water