HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1681553Generated: November 3, 2026
Pyridinium chloride → 5-(3-Carboxybenzoyl)-2-hydroxybenzenepropanoic acid
https://huagongshe.com/reaction/1681553
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 5-[3-(Ethoxycarbonyl)benzoyl]-2-methoxybenzenepropanoic acid, ethyl ester | HCID 14739655 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(3-Carboxybenzoyl)-2-hydroxybenzenepropanoic acid | HCID 14739656 | 91.7% |
Reaction Steps
A mixture of 41.5 g of 5-[3-(ethoxycarbonyl)benzoyl]-2-methoxybenzenepropanoic acid, ethyl ester and 410 g of pyridine hydrochloride were heated at 180° C. for 4 hours. After cooling, water was added to the mixture while hot. As the mixture cooled, the title product precipitated from solution. Filtration of the solids and crystallization from ethanol/water provided 31.1 g of the title product, m.p. 197°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05171882 |
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| Source dataset | uspto-grants-1992_12 |
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| ORD ID | ord-4e4d1e74174240938b9a1e4e69f7e11e |
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| Source note | uspto-grants-1992_12 |
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