Hydrochloric Acid → HCID 19382218, compound

HRID 1681599Notes

Reaction equation

HRID 1681599 reaction equation
[NH2:1][CH2:2][C:3]1([OH:14])[CH2:8][CH2:7][N:6](C(OCC)=O)[CH2:5][CH2:4]1.[ClH:15]>>[ClH:15].[ClH:15].[NH2:1][CH2:2][C:3]1([OH:14])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14049029Ethyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Product 1

HCID 19382218HCID 19382218, compound

Procedure

1 g (4.9 mmol) of ethyl 4-aminomethyl-4-hydroxypiperidine-1-carboxylate is heated overnight under reflux with 10 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

Workup

  1. concentrationThe product is concentrated
  2. customthe crystals are triturated with acetone
  3. filtrationfiltered off with suction
  4. dry with materialdried in a vacuum desiccator over P4O10

Sources & evidence

ORD record
ord-fc6e5f22f34841f78b12c75f6e9f84cb
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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