Methylamine → HCID 19382193, compound

HRID 1681600Notes

Reaction equation

HRID 1681600 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]2)[CH2:2]1.[CH3:14][NH2:15]>>[OH:1][C:3]1([CH2:2][NH:15][CH3:14])[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 13672926Ethyl 1-oxa-6-azaspiro[2,5]octane-6-carboxylate

Product 1

HCID 19382193HCID 19382193, compound

Procedure

5.2 g (28 mmol) of ethyl 6-aza-1-oxaspiro[2,5]octane-6-carboxylate ) are added dropwise to 30 ml of methylamine solution (25% in water) and the mixture is stirred overnight at room temperature. It is then concentrated and recrystallized from petroleum ether (hygroscopic crystals).

Workup

  1. concentrationIt is then concentrated
  2. customrecrystallized from petroleum ether (hygroscopic crystals)

Sources & evidence

ORD record
ord-8c33e78be6dc48f4a77fb7fa652dc59b
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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