Hydrochloric Acid → 4-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

HRID 1681605Notes

Reaction equation

HRID 1681605 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:2].[ClH:17]>>[ClH:17].[ClH:17].[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19382186HCID 19382186, compound

Product 1

HCID 193821764-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

Procedure

4.6 g (20 mmol) of ethyl 4-ethylaminomethyl-4-hydroxypiperidine-1-carboxylate is heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

Workup

  1. concentrationThe product is concentrated
  2. customthe crystals are triturated with acetone
  3. filtrationfiltered off with suction
  4. dry with materialdried in a vacuum desiccator over P4O10

Sources & evidence

ORD record
ord-6f48121b7bdc4fdd935938eac7fa9b6d
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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