Phenethylamine → HCID 19382195, compound

HRID 1681610Notes

Reaction equation

HRID 1681610 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]2([O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([CH2:22][NH2:23])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O>[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]([CH2:11][NH:23][CH2:22][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([OH:12])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 111948055-Benzyl-1-oxa-5-azaspiro[2.4]heptane

Product 1

HCID 19382195HCID 19382195, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

18.2 g (95 mmol) of 5-benzyl-1-oxa-5-azaspiro[2,4]heptane are added dropwise to 15.6 ml (0.115 mol) of benzylmethylamine in 300 ml of water and the mixture is stirred for 15 hours at room temperature. The product is extracted using CH2Cl2, the extracts are dried using K2CO3 and concentrated, and incipient distillation is carried out up to 160° C. (oil bath temperature).

Workup

  1. extractionThe product is extracted
  2. customthe extracts are dried
  3. concentrationconcentrated
  4. distillationincipient distillation
  5. customis carried out up to 160° C. (oil bath temperature)

Sources & evidence

ORD record
ord-30f30f00cbee4d27952e5688438916d4
Source dataset
uspto-grants-1992_12
Patent number
US05173484

Reaction notes

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