反应详情

18.2 g (95 mmol) of 5-benzyl-1-oxa-5-azaspiro[2,4]heptane are added dropwise to 15.6 ml (0.115 mol) of benzylmethylamine in 300 ml of water and the mixture is stirred for 15 hours at room temperature. The product is extracted using CH2Cl2, the extracts are dried using K2CO3 and concentrated, and incipient distillation is carried out up to 160° C. (oil bath temperature).

1. extractionThe product is extracted
2. customthe extracts are dried
3. concentrationconcentrated
4. distillationincipient distillation
5. customis carried out up to 160° C. (oil bath temperature)