反应详情

The solution of 26.5 g (0.11 mol, 93% proof) 1-benzyl-3-cyano-3-methoxypyrrolidine in 300 ml methanol is hydrogenated at 15 g Raney-Ni at 60° C./100 bar H2. The catalyst is removed by filtration, the methanol is removed in vacuo, and the residue is distilled.

1. customThe catalyst is removed by filtration
2. customthe methanol is removed in vacuo
3. distillationthe residue is distilled