Sodium Hydroxide → HCID 66653131, compound

HRID 1681678Notes

Reaction equation

HRID 1681678 reaction equation
Cl.[C:2]([NH:5][CH2:6][CH2:7][NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([OH:4])=[O:3].[OH-].[Na+]>O>[C:2]([NH:5][CH2:6][CH2:7][NH:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([OH:4])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67916546HCID 67916546, compound

Product 1

HCID 66653131HCID 66653131, compoundYield 88.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 19.5 g of the above hydrochloride in 300 ml of water was basified to pH 14 with sodium hydroxide solution. The mixture was stirred for 10 minutes, filtered and the filtrate extracted with three 100 ml portions of dichloromethane. The extracts were combined, washed with brine, dried, filtered and evaporated to dryness, giving 14.5 g of the desired compound as the free base.

Workup

  1. filtrationfiltered
  2. extractionthe filtrate extracted with three 100 ml portions of dichloromethane
  3. washwashed with brine
  4. customdried
  5. filtrationfiltered
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-52ea9746f1dc4506b752cf916d140f9a
Source dataset
uspto-grants-1992_12
Patent number
US05173510

Reaction notes

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