反应详情

Using a similar procedure to that described in Examples 2-16, but starting from N-allyl-4-methoxy-2-nitrobenzamide (itself prepared from 4-hydroxy-2-nitrobenzoic acid using the procedure described in the portion of Example 82 which is concerned with the preparation of starting material except that methyl iodide was used in place of butyl iodide and allylamine was used in place of benzylamine), using a mixture of ethanol and water (4/1 v/v) in place of aqueous methanol as the reaction solvent and having a reaction duration of 3 hours, there was obtained 1,2-dihydro-2-allyl-6-methoxy-3H-indazol-3-one (Ex. 178) as a solid, m.p. 126° C. in 33% yield.

1. customa reaction duration of 3 hours