Hydrochloric Acid → HCID 86746430, compound

HRID 1681712Notes

Reaction equation

HRID 1681712 reaction equation
C[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12](CC3N=CNC=3C)[CH2:13][CH2:14][C:3]=12.[ClH:23]>CO.C(O)C>[ClH:23].[CH:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:2]=[C:3]1[CH:14]=[CH:13][CH2:12][C:11](=[O:22])[N:4]12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 125368FK 1052

Product 1

HCID 86746430HCID 86746430, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 887MethanolSolvent

Procedure

The suspension of 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one (2.0 g) in methanol (60 ml) was treated with hydrogen chloride in ethanol and then diluted with hot aqueous ethanol (water:ethanol, 1:4) to give a clear solution. After filtration of the insoluble materials, the filtrate was evaporated under reduced pressure to about 40 ml and allowed to stand at room temperature overnight. Filtration, followed by washing with ethanol, gave 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl[pyrido[1,2-a]indol-6(7H)-one hydrochloride (2.10 g) as crystals.

Workup

  1. customto give a clear solution
  2. filtrationAfter filtration of the insoluble materials
  3. customthe filtrate was evaporated under reduced pressure to about 40 ml
  4. filtrationFiltration
  5. washby washing with ethanol

Sources & evidence

ORD record
ord-1d79b3fadae047cb9262f2f6cb5d4a57
Source dataset
uspto-grants-1992_12
Patent number
US05173493

Reaction notes

Loading…