4-[4-(1-Piperidinyl)butyl]piperidine → 6,11-Dihydro-11-[[4-[4-(1-piperidinyl)butyl]-1-piperidinyl]-acetyl]-5H-pyrido [2,3-b][1,5]benzodiazepin-5-one

HRID 1681815Notes

Reaction equation

HRID 1681815 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][C:8](=[O:16])[C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].[N:21]1([CH2:27][CH2:28][CH2:29][CH2:30][CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[N:21]1([CH2:27][CH2:28][CH2:29][CH2:30][CH:31]2[CH2:36][CH2:35][N:34]([CH2:2][C:3]([N:5]3[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=4[NH:9][C:8](=[O:16])[C:7]4[CH:17]=[CH:18][CH:19]=[N:20][C:6]3=4)=[O:4])[CH2:33][CH2:32]2)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 143742924-[4-(1-Piperidinyl)butyl]piperidineHCID 1980421711-(chloroacetyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

Product 1

HCID 143743126,11-Dihydro-11-[[4-[4-(1-piperidinyl)butyl]-1-piperidinyl]-acetyl]-5H-pyrido [2,3-b][1,5]benzodiazepin-5-oneYield 37%

Procedure

Prepared analogously to Example 1 from 11-(chloroacetyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 4-[4-(1-piperidinyl)butyl]piperidine in a yield of 37% of theory.

Sources & evidence

ORD record
ord-705068ef6f3243ab84ff616088de5342
Source dataset
uspto-grants-1992_12
Patent number
US05175158

Reaction notes

Loading…