反应详情

To a solution of the product of Step A (1.06 g, 4.28 mmol) in 5 mL of THF at 0° C. was added borane-methyl sulfide (6.42 mL of 2M solution in THF, 12.84 mmol, 3.0 eq). The reaction was allowed to warm to room temperature. After 16 hours the reaction was cooled to 0° C. and quenched with methanol. The volatiles were removed in vacuo and the oil flash chromatographed with 2:1 hexane/ethyl acetate to yield the titled compound (169 mg, 17%). Approximately 80% of the starting material was also recovered.

1. temperatureAfter 16 hours the reaction was cooled to 0° C.
2. customquenched with methanol
3. customThe volatiles were removed in vacuo
4. customthe oil flash chromatographed with 2:1 hexane/ethyl acetate