Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → H2N-Pro MBHA resin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| 반응물 | MBHA resin | HCID 71310119 | — |
| 반응물 | Boc-Pro MBHA resin | HCID 131717703 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 용매 | Diisopropylethylamine | HCID 81531 | — |
| 생성물 | H2N-Pro MBHA resin | HCID 131717702 | — |
반응 단계
Peptides described in this invention are prepared starting from t-butyloxycarbonyl-proline linked to MBHA resin (Boc-Pro-MBHA) which is also commercially available. Boc-Pro-MBHA resin is treated with anhydrous trifluoroacetic acid (TFA) or 25% to 75% mixture of TFA in dichloromethane (TFA-DCM) to deprotect the amino group, and the resulting salt neutralized using 5% to 20% triethylamine in DCM (TEA-DCM) or 5% to 20% diisoproylethylamine in DCM (DIEA-DCM) to furnish H2N-Pro-MBHA resin.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05175146 |
| 출처 데이터셋 | uspto-grants-1992_12 |
| ORD ID | ord-6e90bb00ca8f4d9882e5a721f2d63280 |
| 출처 메모 | uspto-grants-1992_12 |