HRID1681988

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

2 次

HCID85083

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

C10H17NO4

结构：C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.Cc1ccc(C(N)c2ccccc2)cc1.Cl

HCID71310119

未命名化合物

结构：C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O.Cc1ccc(C(N)c2ccccc2)cc1.Cl

HCID131717703

未命名化合物

PRODUCTS

生成物

结构：C=Cc1ccc(C=C)cc1.C=Cc1ccccc1.Cc1ccc(C(N)c2ccccc2)cc1.Cl.O=C(O)[C@@H]1CCCN1

HCID131717702

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

3 次

溶剂HCID8471

Triethylamine

C6H15N

溶剂HCID81531

Diisopropylethylamine

C8H19N

PROCEDURE

实验过程

Peptides described in this invention are prepared starting from t-butyloxycarbonyl-proline linked to MBHA resin (Boc-Pro-MBHA) which is also commercially available. Boc-Pro-MBHA resin is treated with anhydrous trifluoroacetic acid (TFA) or 25% to 75% mixture of TFA in dichloromethane (TFA-DCM) to deprotect the amino group, and the resulting salt neutralized using 5% to 20% triethylamine in DCM (TEA-DCM) or 5% to 20% diisoproylethylamine in DCM (DIEA-DCM) to furnish H2N-Pro-MBHA resin.

WORKUP

后处理

customare prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6e90bb00ca8f4d9882e5a721f2d63280
来源数据集: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05175146
来源说明: uspto-grants-1992_12

反应 SMILES

C(OC([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=O)(C)(C)C.[CH3:16][C:17]1[CH:22]=[CH:21][C:20](C(N)C2C=CC=CC=2)=[CH:19][CH:18]=1.[CH2:31]=[CH:32]C1C=CC=CC=1.[CH2:39]=CC1C=CC(C=C)=CC=1.[ClH:49].N1(C(OC(C)(C)C)=O)CCC[C@H]1C(O)=O.CC1C=CC(C(N)C2C=CC=CC=2)=CC=1.C=CC1C=CC=CC=1.C=CC1C=CC(C=C)=CC=1.Cl.FC(F)(F)C(O)=O>ClCCl.C(N(C(C)C)CC)(C)C.C(N(CC)CC)C>[NH:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11].[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([CH:15]([NH2:8])[C:14]2[CH:13]=[CH:9][CH:10]=[CH:32][CH:31]=2)=[CH:19][CH:18]=1.[CH2:16]=[CH:17][C:10]1[CH:9]=[CH:13][CH:14]=[CH:15][CH:39]=1.[CH2:21]=[CH:22][C:17]1[CH:15]=[CH:14][C:13]([CH:9]=[CH2:10])=[CH:19][CH:18]=1.[ClH:49]