HCID 13292504, compound → HCID 14306844, compound

HRID 1682021Notes

Reaction equation

HRID 1682021 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.Br[CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[CH:12]=1>>[OH:1][CH2:2][CH:3]1[CH2:7][CH2:6][N:5]([CH2:9][CH2:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=3)[CH:12]=2)[CH2:4]1

Participants

3

Reactant 2

HCID 13292504HCID 13292504, compoundHCID 13400657(Pyrrolidin-3-yl)methanol

Product 1

HCID 14306844HCID 14306844, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 3.6 g (29.4 mmol) of 3-hydroxymethyl-pyrrolidine and 4.7 g (14.7 mmol) of 2-(2-bromoethyl)-6-methoxy-naphthalene is heated to 120° C. for 2 hours. The reaction mixture is purified over 200 g of silica gel (0.063-0.2 mm) with methylene chloride and then with increasing amounts of ethanol (up to 5%).

Workup

  1. customThe reaction mixture is purified over 200 g of silica gel (0.063-0.2 mm) with methylene chloride

Sources & evidence

ORD record
ord-e5d44a641f6a4a039ad2b5d69bd939fb
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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