HCID 14306769, compound → HCID 14306777, compound

HRID 1682056Notes

Reaction equation

HRID 1682056 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[N:8][CH:7]=[C:6]2[CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH2:20][CH:19]([CH2:23][N:24]2[C:30](=[O:31])[CH2:29][C:28]3[CH:32]=[C:33]([O:38][CH3:39])[C:34]([O:36][CH3:37])=[CH:35][C:27]=3[CH:26]=[CH:25]2)[CH2:18]1.[H][H]>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[N:8][CH:7]=[C:6]2[CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][CH2:20][CH:19]([CH2:23][N:24]2[C:30](=[O:31])[CH2:29][C:28]3[CH:32]=[C:33]([O:38][CH3:39])[C:34]([O:36][CH3:37])=[CH:35][C:27]=3[CH2:26][CH2:25]2)[CH2:18]1

Participants

5

Reactant 2

HCID 14306769HCID 14306769, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14306777HCID 14306777, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Prepared from 3-[(N-(2-(6,7-dimethoxy-isoquinol-4-yl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-2-oxo-1,3-dihydro-2H-3benzazepine by hydrogenation at 5 bar hydrogen pressure with 10% palladium/charcoal in ethanol at 70° C. analogously to Example 5.

Sources & evidence

ORD record
ord-ec2216a7d2b44be8864258b11b7246fe
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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