3-[(piperidin-3-yl)-methyl]-7,8-dimethoxy1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → 3-[(N-(2-(4-Methoxy-benzo[b]thien-3-yl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-2-oxo-1,3,4,5-tetrahydro-2H-3-benzazepine-hydrochloride

HRID 1682061Notes

Reaction equation

HRID 1682061 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]2[C:14](=[O:15])[CH2:13][C:12]3[CH:16]=[C:17]([O:22][CH3:23])[C:18]([O:20][CH3:21])=[CH:19][C:11]=3[CH2:10][CH2:9]2)[CH2:2]1.[Cl:24][CH2:25][CH2:26][C:27]1[C:28]2[C:35]([O:36][CH3:37])=[CH:34][CH:33]=[CH:32][C:29]=2[S:30][CH:31]=1>>[ClH:24].[CH3:37][O:36][C:35]1[C:28]2[C:27]([CH2:26][CH2:25][N:1]3[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][N:8]4[C:14](=[O:15])[CH2:13][C:12]5[CH:16]=[C:17]([O:22][CH3:23])[C:18]([O:20][CH3:21])=[CH:19][C:11]=5[CH2:10][CH2:9]4)[CH2:2]3)=[CH:31][S:30][C:29]=2[CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 198038413-[(piperidin-3-yl)-methyl]-7,8-dimethoxy1,3,4,5-tetrahydro-2H-3-benzazepin-2-oneHCID 198041093-(2-Chloroethyl)-4-methoxy-benzo[b]thiophene

Product 1

HCID 679177243-[(N-(2-(4-Methoxy-benzo[b]thien-3-yl)-ethyl)-piperidin-3-yl)-methyl]-7,8-dimethoxy-2-oxo-1,3,4,5-tetrahydro-2H-3-benzazepine-hydrochloride

Procedure

Prepared from 3-[(piperidin-3-yl)-methyl]-7,8-dimethoxy-2-oxo-1,3,4,5-tetrahydro-2H-3-benzazepine and 3-(2-chloroethyl)-4-methoxy-benzo[b]thiophene analogously to Example 1.

Sources & evidence

ORD record
ord-12ca4ea9486f4eb8b7c6aae6d2533a04
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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