7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one → 3-[(N-(3-(3-Methyl-phenoxy)-propyl)-hexahydro-azepin-3-yl)methyl]-7,8-dimethoxy-2-oxo-1,3,4,5-tetrahydro-2H-3-benzazepinehydrochloride

HRID 1682071Notes

Reaction equation

HRID 1682071 reaction equation
[CH3:1][O:2][C:3]1[C:14]([O:15][CH3:16])=[CH:13][C:6]2[CH2:7][C:8](=[O:12])[NH:9][CH2:10][CH2:11][C:5]=2[CH:4]=1.[CH3:17][C:18]1[CH:19]=[C:20]([CH:34]=[CH:35][CH:36]=1)[O:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]([CH2:32][Cl:33])[CH2:26]1>>[ClH:33].[CH3:17][C:18]1[CH:19]=[C:20]([CH:34]=[CH:35][CH:36]=1)[O:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]([CH2:32][N:9]2[C:8](=[O:12])[CH2:7][C:6]3[CH:13]=[C:14]([O:15][CH3:16])[C:3]([O:2][CH3:1])=[CH:4][C:5]=3[CH2:11][CH2:10]2)[CH2:26]1

Participants

3

Reactant 2

HCID 114017697,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-oneHCID 19803932N-[3-(3-methyl-phenoxy)-propyl]-3-chloromethylhexahydro-azepine

Product 1

HCID 679182233-[(N-(3-(3-Methyl-phenoxy)-propyl)-hexahydro-azepin-3-yl)methyl]-7,8-dimethoxy-2-oxo-1,3,4,5-tetrahydro-2H-3-benzazepinehydrochloride

Procedure

Prepared from 7,8-dimethoxy-2-oxo-1,3,4,5-tetrahydro-2H-3-benzazepine and N-[3-(3-methyl-phenoxy)-propyl]-3-chloromethylhexahydro-azepine analogously to Example 2.

Sources & evidence

ORD record
ord-0a901e3300ce4e45a724f8b1a8db9b3a
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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