Hydrochloric Acid → HCID 21612957, compound

HRID 1682272Notes

Reaction equation

HRID 1682272 reaction equation
[NH2:1][CH:2](/[CH:6]=[CH:7]/[CH2:8][PH2:9])[C:3]([OH:5])=[O:4].Cl.[CH2:11](O)[CH3:12]>>[CH2:11]([O:4][C:3](=[O:5])[CH:2]([NH2:1])/[CH:6]=[CH:7]/[CH2:8][PH2:9])[CH3:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 19804985HCID 19804985, compound

Product 1

HCID 21612957HCID 21612957, compound

Procedure

1.0 g of E-2-amino-5-phosphino-3-pentenoic acid is suspended in 20 ml of ethanol and the suspension is saturated with hydrogen chloride gas for 2 hours at 65°. After concentration, the residue is dissolved in 10 ml of ethanol, 10 ml of propylene oxide are added and the precipitate is filtered off. Recrystallisation from water/acetone 1:1 yields E-2-amino-5-phosphino-3-pentenoic acid ethyl ester, m.p. 172°-173°.

Workup

  1. concentrationAfter concentration
  2. dissolutionthe residue is dissolved in 10 ml of ethanol
  3. addition10 ml of propylene oxide are added
  4. filtrationthe precipitate is filtered off
  5. customRecrystallisation from water/acetone 1:1

Sources & evidence

ORD record
ord-45321026192b47199c9404d2e71725e2
Source dataset
uspto-grants-1992_12
Patent number
US05175344

Reaction notes

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