Hydrochloric Acid → HCID 21612912, compound

HRID 1682273Notes

Reaction equation

HRID 1682273 reaction equation
[NH2:1][CH:2](/[CH:6]=[CH:7]/[CH2:8][PH2:9])[C:3]([OH:5])=[O:4].Cl>C(O)CCC>[CH2:3]([O:4][C:3](=[O:5])[CH:2]([NH2:1])/[CH:6]=[CH:7]/[CH2:8][PH2:9])[CH2:2][CH2:6][CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19804985HCID 19804985, compound

Product 1

HCID 21612912HCID 21612912, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

1.0 g of E-2-amino-5-phosphino-3-pentenoic acid is suspended in 20 ml of n-butanol and the suspension is saturated with hydrogen chloride gas for 3 hours at 60°. After concentration, the residue is dissolved in 15 ml of n-butanol, 10 ml of propylene oxide are added and the precipitate is filtered off. Recrystallisation from water/acetone 1:1 yields E-2-amino-5-phosphino-3-pentenoic acid butyl ester, m.p. 160°-161°.

Workup

  1. concentrationAfter concentration
  2. dissolutionthe residue is dissolved in 15 ml of n-butanol
  3. addition10 ml of propylene oxide are added
  4. filtrationthe precipitate is filtered off
  5. customRecrystallisation from water/acetone 1:1

Sources & evidence

ORD record
ord-a3f9d97e761049f599cb61a055cec4fe
Source dataset
uspto-grants-1992_12
Patent number
US05175344

Reaction notes

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